RAF Typhoon FGR4s have joined forces with France's air force in a joint strike against an subterranean weapons facility in Syrian territory used by the IS group, according to the UK's MoD.
The location, pinpointed through surveillance, was assessed as containing munitions and bombs, the release indicated, and was situated in mountains just north of the ancient city of Palmyra in Syria's central region.
"Our fighter planes utilized laser-guided Paveway IV weapons to target a number of access tunnels down to the facility... preliminary assessments are that the target was engaged successfully," the ministry announced.
There was no evidence of any civilian casualties in the strike on Saturday evening and every plane involved returned to base without incident, the MoD added.
The Typhoon fighters were supported by a Voyager aerial refuelling aircraft.
Daesh - referred to as ISIS - established militant control over large swathes of both Syria and Iraq until 2019.
"This operation underscores our UK leadership, and commitment to stand shoulder to shoulder with our partners, to stamp out any resurgence of the terrorist group and their dangerous and violent ideologies in the region," the British Defence Secretary the Defence Secretary stated.
RAF aircraft have performed surveillance missions over Syrian airspace to "prevent any attempted resurgence" of Islamic State following its routing at the Baghuz confrontation in the year 2019, the authorities noted.
"I want to thank the personnel of British forces participating in this mission for their expertise and their bravery," he added. "They were part of numerous British personnel on duty over the holidays. This action, to eliminate terrorist threats who threaten our way of life, highlights how our armed forces are ready to step up, continuously, ensuring Britain's security domestically and powerful internationally."
Last December, the American forces executed what it called a "major assault" against Daesh sites in Syria, subsequent to an ambush claimed the lives of two US troops and a civilian interpreter in Palmyra.
The United Nations reports Daesh still boasts an estimated 5,000 to 7,000 fighters in both countries.